First International Conferences on Advanced Pharmacy and Pharmaceutical Sciences, Presented by Faculty of Pharmacy, Universitas Indonesia
APPLICATION OF IONIC LIQUID BASED MICROWAVE-ASSISTED EXTRACTION OF THE SECONDARY METABOLITE FROM PEPEROMIA PELLUCIDA (L) KUNTH.
Islamudin Ahmad1,2, Arry Yanuar1, Kamarza Mulia3, Abdul Mun’im1*
1Departement of Pharmaceutical Sciences, Pharmacy Faculty of Universitas Indonesia, Depok, West Java, Indonesia
2Departement of Pharmaceutical Sciences, Pharmacy Faculty of Mulawarman University, Samarinda, East Kalimantan, Indonesia
3Departement of Chemical Engineering, Engineering Faculty of Universitas Indonesia, Depok, West Java, Indonesia
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ABSTRACT: An ionic liquid (ILS) is a new alternative solvent (containing cations and anions) has the physical and specific solutions properties, and also had proven to be a promising substituent of conventional organic solvents are flammable, volatile and toxic in various processes. The ILS application in separating the secondary metabolites compound from Peperomia pellucida (L) Kunth herbaceous can be carried out using microwave-assisted extraction method (MAE). The aim of this study to investigate the effect of ionic liquid based microwave-assisted extraction method for attracting the secondary metabolites compound from P. pellucida compared with a conventional solvent for the enrichment of secondary metabolites (especially polyphenols group) and their HPTLC fingerprinting profile. The herb dried powder extracted by microwave-assisted extraction using an ionic liquid such us 1-Butyl-3-methylimidazolium chloride ([BMIM]Cl), 1-Butyl-3-methylimidazolium Bromide ([BMIM]Br). The obtained extract solution was partitioned using an organic solvent; the extract was evaporated to obtain a dry extract and determination the HPTLC fingerprinting profile. Based on the research results was obtained from the various types of solvents there are differences in the extraction of secondary metabolite.
Key Word: Ionic liquid, microwave-assisted extraction, Peperomia pellucida (L) Kunth, Secondary metabolite, HPTLC Profile